A rare case of PDGFRA1 mutation positive eosinophilic leukemia presenting as loeffler endocarditis

ABHISHEK GAIKWAD, YASMIN KHAN

Abstract


History- A 35 year old male got admitted with history of abdominal pain and low gradeĀ  fever.

Blood Investigations -His routine blood investigations showed raised total leucocyte count of 26000.Absolute eosinophil count was 20,000.Liver and kidney function test was normal

Ultrasound abdomen showed spleenomegaly.

2D Echo-Transthoracic echocardiogram was done suggestive of obliteration of apex of both ventricles.Diastolic function showed restrictive pattern .(fig 1)

Cardiac MRI was done suggestive of infiltrative cardiomyopathy .(fig 2,3)

Bone marrow and cytogenetic study was done suggestive of PDGRFa1 mutation positive eosinophilic leukemia.

Patient was started on imatinib and patient responded well to treatment with reduction of eosinophil counts.


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